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目的:观察枳苓六妙口服液对小鼠的抗疲劳作用。方法:采用高、中、低不同剂量枳苓六妙口服液给正常小鼠连续灌胃30 d,测定其小鼠力竭游泳时间;运动小鼠血中血红蛋白、乳酸、尿素氮、肝糖原含量及乳酸脱氢酶活性。结果:与对照组比较,枳苓六妙口服液高、中剂量组均能明显延长小鼠的游泳时间,同时能明显提高小鼠血中血红蛋白和降低尿素氮含量(P<0.05或0.01);高、中剂量组均能显著降低血中乳酸含量和显著提高乳酸脱氢酶活性(P<0.01);低剂量、中剂量和高剂量组能明显提高肝糖原含量(P<0.05或0.01)。结论:枳苓六妙口服液具有显著的抗疲劳作用,其中360 mg·kg~(-1)效果最佳。
Objective: To observe the anti-fatigue effect of Zhiliuling Liu Miao oral liquid on mice. Methods: Normal mice were fed with high, medium and low doses of Zhiliuolianlian Oral Liquid continuously for 30 days. The exhaustive swimming time of mice was measured. Hemoglobin, lactate, urea nitrogen, Content and lactate dehydrogenase activity. Results: Compared with the control group, both the high dose and middle dose of Zhili Ling Liu Miaowei oral liquid could prolong the swimming time of mice and significantly increase the hemoglobin and the content of urea nitrogen (P <0.05 or 0.01). Both high dose and middle dose groups could significantly reduce the content of lactic acid in blood and increase the activity of lactate dehydrogenase significantly (P <0.01). The content of hepatic glycogen in low dose, medium dose and high dose groups could significantly increase the content of hepatic glycogen (P <0.05 or 0.01) . Conclusion: Zhili Ling Liu Miao oral liquid has significant anti-fatigue effect, of which 360 mg · kg -1 is the best.