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内毒素血症是临床上较难控制的一种疾病，死亡率高达20％～60％。其诊断试验——鲎试验，因其非特异性的缺陷，经常出现假阳性结果，给临床造成误诊。内毒素单克隆抗体自问世以来，迅速发展，为内毒素血症提供了特异、敏感、快速的诊断工具，为其治疗提供了一种特异的免疫制剂。但是，它的应用却受到了内毒素种属差异和体内外各种因素的限制。本文对该方面的研究现状作一综述。
Endotoxemia is a disease that is more difficult to control clinically, with a mortality rate of 20% -60%. Its diagnostic test - 鲎 test, because of its non-specific defects, often false positive results, resulting in clinical misdiagnosis. The rapid development of endotoxin monoclonal antibodies since its inception has provided a specific, sensitive and rapid diagnostic tool for endotoxemia and provided a specific immunological preparation for its treatment. However, its application has been limited by endotoxin species and various factors in vivo and in vitro. This article reviews the research status of this aspect.