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1960年布洛(Bullough)等人在实验性皮肤创伤中发现表皮细胞的有丝分裂,可被自体皮肤产生的一种因子所调节,并于1965年被证实,以后将此种因子定名为“表皮抑素”
In 1960, Bullough et al found that epidermal cell mitosis in experimental skin wounds was regulated by a factor produced by autologous skin and was confirmed in 1965. Later, the factor was named “epidermis SST ”