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目的:研究人细小病毒B19,B族链球菌和解脲支原体与早产的关系。方法:应用聚合酶链反应技术(PCR)检测早产350例及足月产500例患者胎盘,胎膜中的3种病原体DNA。结果:早产组人细小病毒B19,B族链球菌和解脲支原体的感染率分别为14.88%、23.24%及20.53%,明显高于对照组。早产组2种以上病原体感染者92例,占26.28%,而对照组无多种病原体感染。结论:早产可以由一种病原体感染引起,也可以是多种病原体感染的后果。人细小病毒B19是引起早产的主要病原体之一。
Objective: To study the relationship between human parvovirus B19, Streptococcus group B and Ureaplasma urealyticum and preterm labor. Methods: The DNA of three kinds of pathogens in placenta and fetal membranes of 350 preterm and 500 full term pregnant women were detected by polymerase chain reaction (PCR). Results: The prevalence of human parvovirus B19, B streptococci and Ureaplasma urealyticum were 14.88%, 23.24% and 20.53% respectively in preterm labor group, which were significantly higher than those in control group. In the preterm group, 92 cases were infected with more than 2 pathogens, accounting for 26.28%, while the control group had no more pathogens. Conclusions: Preterm birth can be caused by a single pathogen infection or as a consequence of multiple pathogen infections. Human parvovirus B19 is one of the major pathogens causing preterm birth.