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目的探讨小剂量沙利度胺治疗白塞病的临床价值。方法 80例白塞病患者,随机分为观察组与参考组,各40例,分别给予两组患者小剂量沙利度胺、大剂量沙利度胺治疗,观察两组患者临床治疗效果、不良反应发生情况及复发情况。结果两组患者临床治疗总有效率为92.5%、95.0%,两组比较差异无统计学意义(P>0.05);观察组不良反应发生率显著低于参考组(P<0.05);两组患者1年内复发率比较差异无统计学意义(P>0.05)。结论小剂量沙利度胺治疗白塞病即能达到有效效果,能够有效减少不良反应,复发率较低,可在临床推广使用。
Objective To investigate the clinical value of low-dose thalidomide in the treatment of Behcet’s disease. Methods Eighty patients with Behcet’s disease were randomly divided into observation group and reference group, 40 cases in each group. Patients in two groups were given low-dose thalidomide and high-dose thalidomide respectively. The clinical effects, Response and recurrence of the situation. Results The total effective rate of clinical treatment was 92.5% and 95.0% in both groups, with no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the reference group (P <0.05) There was no significant difference in recurrence rate in one year (P> 0.05). Conclusion Low-dose thalidomide can effectively treat Behcet’s disease, effectively reduce adverse reactions, and has a low recurrence rate. It can be used clinically.