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乙胺碘呋酮(A)对治疗反复的室速常有效,但也有许多严重副作用,除神经、眼、肺毒性和甲状腺功能改变外,还可致室速恶化;常为扭转性室速.方法:本文病例为证实因 A 而致心律失常恶化.被证明为:①出现新的室速和/或在开始 A 治疗后心动过速发生特殊的变化.②停 A 后上述改变消失.所谓新的室速指不同形态/或比前更快速度(至少快30次/分)的室速.室速型的变化指复发的频率比前至少增加5倍,这些形态、速率、复发频率由动态或遥测心电图证实.A 负荷量期为5—8天,剂置800—1400mg/日,维持量400—1000mg/日.全部患者均未同时用其他抗心律失常药,并停用过去服用抗心律失常药至少5个半衰期.
Amiodarone (A) is often effective in treating recurrent ventricular tachycardia but has many serious side effects. In addition to neurological, ocular, pulmonary toxicities and thyroid function changes, it can also cause deterioration of ventricular tachycardia; often torsades de pointes. Methods: This case demonstrates the worsening of arrhythmia due to A. It has been demonstrated that: ① new VTs and / or special changes in tachycardia occur after initiation of treatment A. ② the above changes disappear after stopping A. The so-called new Of ventricular tachycardia refers to ventricular tachycardia in different modalities / or faster than before (at least 30 beats / min.) Variations in VT indicate a relapse rate of at least 5-fold greater than before, and these patterns, rates, Or telemetry electrocardiogram confirmed .A load period of 5-8 days, 800-400mg dosage 800-400mg / day, the maintenance dose 400-1000mg / day .All patients were not at the same time with other antiarrhythmic drugs, and the withdrawal of the past taking anti-rhythm Disorders at least 5 half-lives.