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目的:探讨健骨胶囊对骨性关节炎模型兔关节软骨组织中蛋白聚糖含量的影响。方法:建立早期软骨退变降解的骨性关节炎动物模型,将模型动物分为模型组、健骨胶囊低、中、高剂量组和正常对照组,采用生物化学方法测定蛋白聚糖的含量。结果:给骨性关节炎模型兔连续喂服健膏胶囊14 d后,可显著地提高兔膝关节软骨中蛋白聚糖含量。结论:健骨胶囊可能对骨性关节炎有一定的改善和治疗作用。
Objective: To investigate the effect of Jiangu Capsule on proteoglycan content in articular cartilage of rabbits with osteoarthritis. METHODS: An animal model of osteoarthritis degraded by early cartilage degeneration was established. Model animals were divided into model group, Jiangu capsule low, middle and high dose group and normal control group. The content of proteoglycan was determined by biochemical method. RESULTS: After 14 days of continuous feeding of Jianpeng capsules in rabbits with osteoarthritis, the proteoglycan content in rabbit knee joint cartilage could be significantly increased. Conclusion: Jiangu capsule may have some improvement and treatment effect on osteoarthritis.