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目的探讨三维适形放疗在食管癌纵隔转移淋巴结治疗的临床价值。方法收集2006年1月～2008年1月间某院治疗的资料完整的182例食管癌纵隔转移淋巴结患者临床资料,行三维适形放疗的120例为观察组,其余接受常规放疗治疗的62例为对照组,比较两组的近期疗效、毒副作用及近、远期生存率。结果行三维适形放疗观察组患者CR比例为53.3%,PR比例为35.0%,缓解率为88.3%,均显著高于对照组;而3年生存率为21.7%,也显著高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者治疗后,急性放射性食管炎、急性放射性气管炎及急性放射肺炎等并发症为III和IV的比例分布为13.4%,17.5%,14.1%,均较对照组显著降低(P﹤0.05)。结论三维适形放疗可显著提高患者生存率,且治疗后毒副反应降低。
Objective To investigate the clinical value of three-dimensional conformal radiotherapy in mediastinal lymph node metastasis of esophageal cancer. Methods The clinical data of 182 patients with mediastinal lymph node metastasis from January 2006 to January 2008 in our hospital were collected. One hundred and twenty-three patients undergoing three-dimensional conformal radiotherapy were selected as the observation group, and the other 62 patients undergoing conventional radiotherapy For the control group, the two groups were compared the short-term efficacy, side effects and short-term, long-term survival. Results The CR rate was 53.3% in the three-dimensional conformal radiotherapy observation group, the PR rate was 35.0%, the remission rate was 88.3%, which was significantly higher than that of the control group; while the 3-year survival rate was 21.7%, which was significantly higher than that of the control group The differences were statistically significant (P <0.05). After treatment, the proportion of III and IV in acute radiation esophagitis, acute radiation bronchitis and acute radiation pneumonia were 13.4%, 17.5% and 14.1% respectively in the observation group, which were significantly lower than those in the control group (P <0.05) . Conclusion Three-dimensional conformal radiotherapy can significantly improve the survival rate of patients, and reduce the side effects after treatment.