内镜黏膜下剥离术(endoscopic submucosal dissection,ESD)是由日本内镜医师发明的用于早期胃肠道恶性病灶整块切除的一种微创技术。现在在世界范围内已广泛开展,ESD提高了较大的早期胃肠道肿瘤整块切除的成功率。新设备和新技术的应用使ESD得到了很大的改进,如今ESD切除范围已经从胃扩展到了消化道其他黏膜区域,如食管、十二指肠、结肠和直肠,而且对于直径超过2cm的消化道表浅肿瘤,ESD明显优于内镜下黏膜切除术(EMR),有较高的根治率,减少复发的风险,并可更好的进行组织学评估,最近的报道显示ESD提高了胃肠道肿瘤的五年总体生存率。2006年起国内也 Endoscopic submucosal dissection (ESD) is a minimally invasive technique invented by endoscopists in Japan for the resection of early malignant lesions of the gastrointestinal tract. It is now widely available worldwide that ESD increases the success rate of larger en bloc resections of early gastrointestinal cancers. The use of new equipment and new technologies has greatly improved ESD, and the scope of ESD resection has now extended from the stomach to other mucosal areas of the digestive tract, such as the esophagus, duodenum, colon and rectum, and for digestion over 2 cm in diameter ESD is superior to endoscopic mucosal resection (EMR) in the treatment of superficial tumors and has a high cure rate, a reduced risk of relapse and better histologic evaluation. Recent reports show that ESD increases gastrointestinal Five-year overall tumor survival rate. Since 2006 also domestic