最近进行的动物试验表明,氟化物有潜在致癌作用,可使啮齿动物骨癌发病率升高。为探讨人类骨癌发病率与饮水加氟的关系,作者进行了这次研究和分析。研究对象为纽约州居民,人口统计学资料来源于该州每十年一次进行的人口调查。骨癌及骨肉瘤病例资料取自该州癌症统计处,诊断标准以国际疾病分类法第9版为依据,因纽约市区的癌症资料不完整,分析中予以剔除。该州的奥尔巴尼、萨福克及拿骚三县为非加氟饮用水区域,其余各县从五十年代或六十年代初 Recent animal tests have shown that fluoride has a potential carcinogenic effect that can increase the incidence of bone cancer in rodents. In order to explore the relationship between the incidence of human bone cancer and fluoride in drinking water, the author conducted this study and analysis. The study population was New York State residents. Demographic data were collected from the state’s census every ten years. Bone cancer and osteosarcoma case data were obtained from the state Cancer Institute and the diagnostic criteria were based on the 9th edition of the International Classification of Diseases because of the incomplete cancer data in New York City. The state of Albany, Suffolk and Nassau counties are non-fluoride drinking water areas, the rest of the county from the fifties or early sixties