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目的观察瑞舒伐他汀对急性心肌梗死(AMI)大鼠血清基质金属蛋白酶-9(MMP-9)和肿瘤坏死因子-α(TNF-α)的影响,探讨其防治AMI后心室重构的作用机制。方法40只SD大鼠随机选取10只作为假手术组,剩下30只结扎左前降支建立 AMI动物模型,将术后24 h 存活的20只大鼠随机分为模型组和瑞舒伐他汀组,4周后分别检查各组大鼠血流动力学指标和血清 MMP-9、TNF-α含量。结果模型组的平均动脉压(MAP)、左心室内压最大上升速度(+dp/dtmax )、左心室内压最大下降速度(-dp/dtmax )降低,左心室舒张末压(LVEDP)及血清 MMP-9、TNF-α升高,与假手术组比较差异均有显著性(P <0.01)；瑞舒伐他汀组 MAP、+dp/dtmax、-dp/dtmax升高,LVEDP、MMP-9、TNF-α降低,与模型组比较差异均有统计学意义(P<0.05或P<0.01)。结论瑞舒伐他汀可减轻 AMI后的心室重构,其作用机制可能与调节血清 MMP-9、TNF-α水平变化有关。“,”Objective]To observe the effect of rosuvastatin on serum matrix metalloproteinase-9(MMP-9)and tumor necrosis factor-alpha(TNF-α)in rats with acute myocardial infarction(AMI),and to explore the action mechanism for prevention and treatment of ventricular remodeling after AMI.[Methods]Among 40 SD rats,10 rats were randomly selected as the sham group and the remaining 30 rats underwent the ligation of left anterior de-scending branch to establish AMI animal model.After 24h,20 survival rats were randomly divided into model group and the rosuvastatin group.Hemodynamic indexes and serum levels of MMP-9 and TNF-αin rats of each group were examined after 4 weeks.[Results]The MAP,+ dp/dtmax and -dp/dtmax were decreased,and LVEDP and serum MMP-9 and TNF-αwere increased in model group,and there was significant difference between model group and sham group(P<0.01).In rosuvastatin group,MAP,+ dp/dtmax and -dp/dtmax were increased,and LVEDP,MMP-9 and TNF-αwere decreased,and there was significant difference between model group and sham group(P<0.05 or P<0.01).[Conclusion]Rosuvastatin can reduce ventricular remodeling after AMI.Its mech-anism may be related to the regulation of serum MMP-9 and TNF-α.