清胃祛湿方对Hp相关性慢性胃炎感染临床研究

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目的:观察清胃祛湿方对比三联抗菌疗法治疗幽门螺杆菌(Helicobacter pylori即Hp)相关性慢性胃炎临床疗效分析对比.方法:随机选取2013年1月~2015年1月在如皋市人民医院确诊病治疗的患者110例.以随机方式分为2组,选择60例为治疗组,给予清胃祛湿方治疗(中药治疗组给予清胃祛湿方,该方由川楝子10g,延胡索15g,蒲公英15g,对花蛇舌草15g,茵陈15g,黄连10g等药物组成,每日1剂).50例为对照组,采用三联抗菌疗法治疗法治疗.并对治疗组和对照组治疗后的根除率及症状、身体状况进行比较.若治疗组患者经治疗后仍呈阳性或对本研究较积极的患者,给予巩固治疗2个月.并对经巩固治疗患者前后的康复率及身体状况进行比较,并对治疗前后患者各项特征进行记录分析.同时测定患者血清免疫复合物Hp-IC及血清Hp特异性IgG抗体(Hp-IgG)进行疗效评价.结果:Hp两种治疗方法作用比较:治疗之后,治疗组总有效率为36.5%,对照组总有效率10%,两组对比有差异(P<0.05),治疗组疗效优于对照组.康复率比较:治疗组HP康复率为47%,对照组HP康复率为78%.两组康复率对比有差异(P<0.05),对照组HP康复率高于治疗组;治疗组治疗前后血清Hp-IC含量(mg/L)分别为0.863±0.374、0.141±0.097,血清Hp-IgG含量(mg/L)分别为34.1±30.3、31.7±29.4;对照组治疗前后血清Hp-IC含量(mg/L)分别为0.857±0.369、0.361±0.083,血清Hp-IgG含量(mg/L)分别为33.6±29.6,32.8±25.6,两组治疗后Hp-IC、Hp-IgG对比,P<0.05,差异有统计学意义.结论:清胃祛湿方治疗幽门螺杆菌(Helicobacter pylori即Hp)相关性慢性胃炎HP康复率为47%,有较积极的作用,但对比三联抗菌疗法仍存在差异,清胃祛湿方治疗后血液Hp-IC、Hp-IgG含量与常规治疗对比均下降明显,且清胃祛湿方治疗幽门螺杆菌(Helieobacter pylori,Hp)相关性慢性胃炎病毒副反应基本无显现.“,”Objective:To observe the clinical curative effect of Qingwei Qushi Decoction on the treatment of Helicobacter pylori (Hp) related chronic gastritis compared with triple antibacterial therapy.Methods:Randomly selected from January 2013to January 2015in Rugao People's Hospital of patients diagnosed with ll0cases for treatment.They were ramdomly divided into 2groups,60cases in the treatment group were given Qingwei Qushi Decoction.50cases in the controlled group,were given triple antibacterial therapy.And the eradication rate and the symptoms and physical condition of the treatment group and the controlled group were compared.If the treatment group were still positive after treatment or more active in patients with this study,to give consolidation therapy for 2months.The rehabilitation rate and physical condition of the patients before and after consolidation therapy were compared,and the characteristics of patients before and after treatment were recorded and analyzed.(Hp-IC) and serum Hp-specific IgG antibody (Hp-IgG) were determined in the same time.Results:The total effective rate of the treatment group was 36.5% and the total effective rate of the controlled group was 10%.There was significant difference between the two groups (P < 0.05).The therapeutic effect of the treatment group was better than that of the controlled group.The rate of rehabilitation was 47% in the treatment group and 78% in the controlled group.The levels of Hp-IC in the treatment group were 0.863 ±0.374,0.141±0.097before and after treatment,and the levels of serum Hp-IC in the treatment group were significantly higher than those in the controlled group (P < 0.05).The serum Hp-IC content (mg/L) in the controlled group was 0.857±0.369,0.361±0.083,and the serum Hp-IgG content (mg/L) were 33.6±29.6and 32.8±25.6respectively.There was significant difference in Hp-IC and Hp-IgG between the two groups after treatment,P < 0.05,the difference was statistically significant.Conclusion:Qingre Qushi Recipe treatment of Helicobacter pylori (Helicobacter pylori or Hp) related chronic gastritis HP rehabilitation rate of 47%,a more positive role,but there are still differences compared to triple antibacterial therapy,Qingwei Qushi Recipe treatment of blood Hp IgG,Hp-IgG and Hp-IgG in the treatment of Helicobacter pylori (Hp) related chronic gastritis were not significantly different from those in the controlled group.
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