患者男性 ,6 2岁 ,既往无肝肾及出血病史。 4年前因风湿性心脏病行瓣膜置换术。 4年来每日口服华法令 2 .5～ 3mg,凝血酶原时间 (PT)保持 2 5s左右 ,无出血现象。因心房颤动口服胺碘酮 0 .2 ,每日 2次后 ,出现出血现象 ,经调整两药用量 ,PT恢复正常 ,出血症状消失。提示华法令和胺碘酮合用能引起凝血功能障碍 Male patients, 6 2 years old, no past history of liver and kidney disease and bleeding. 4 years ago due to rheumatic heart disease valve replacement surgery. 4 years of daily oral warfarin 2.5 ~ 3mg, prothrombin time (PT) to maintain about 25s, no bleeding. Due to atrial fibrillation oral amiodarone 0 .2, 2 times a day after bleeding, after adjusting the amount of two drugs, PT returned to normal, bleeding symptoms disappear. Prompt warfarin and amiodarone can cause coagulation disorders