【摘 要】
：
The unpleasant sensations itch and pain induce distinct behavioral patterns.Although both acute itch and pain serve protective functions, they are different sen
【机 构】
：
Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow Universit
论文部分内容阅读
The unpleasant sensations itch and pain induce distinct behavioral patterns.Although both acute itch and pain serve protective functions, they are different sensory modalities.Itch stimuli lead to the scratching reflex or the desire to scratch, which may be helpful for removing potential irritants.In contrast, pain stimuli lead to withdrawal behaviors but not scratching [1].Chronic itch and pain are significant clinical symptoms of many systemic diseases, and markedly reduce the quality of life of affected patients.Clinically, effective treatments for chronic itch and pain are still limited.The incomplete understanding of how itch and pain are processed by the somatosensory system is a major hurdle to developing new effective analgesics and itch relievers.
其他文献
Oxidative stress is the key determinant in the pathogenesis of noise-induced hearing loss(NIHL).Given that cellular defense against oxidative stress is an energ
Neuronal ensembles with distinct morphological, biochemical, and functional identities are organized into complex circuits in the mammalian brain, and malfuncti
Stem cell transplantation holds a promising future for central nervous system repair.Current chal-lenges,however,include spatially and temporally defined cell d
Chordotonal neurons are responsible for sound sensation in Drosophila.However,little is known about how they respond to sound with high sensitivity.Using geneti
Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest.They have been developed from herpes
Dear Editor,nEmergency intravascular thrombectomy is the best treat-ment for acute ischemic stroke[1].However,it is controversial whether the use of general ane
Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated.Toll-like receptors (TLRs) have
Remifentanil is widely used to control intraoperative pain.However,its analgesic effect is limited by the generation of postoperative hyperalgesia.In this study
The present study was designed to investigate the mechanisms by which P2X7 receptors(P2X7Rs)mediate the activation of vasopressinergic neurons thereby increasin