【摘 要】
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The unpleasant sensations itch and pain induce distinct behavioral patterns.Although both acute itch and pain serve protective functions, they are different sen
【机 构】
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Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow Universit
论文部分内容阅读
The unpleasant sensations itch and pain induce distinct behavioral patterns.Although both acute itch and pain serve protective functions, they are different sensory modalities.Itch stimuli lead to the scratching reflex or the desire to scratch, which may be helpful for removing potential irritants.In contrast, pain stimuli lead to withdrawal behaviors but not scratching [1].Chronic itch and pain are significant clinical symptoms of many systemic diseases, and markedly reduce the quality of life of affected patients.Clinically, effective treatments for chronic itch and pain are still limited.The incomplete understanding of how itch and pain are processed by the somatosensory system is a major hurdle to developing new effective analgesics and itch relievers.
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