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虽然前列腺素D_2为人肺的肥大细胞分泌量最多的前列腺素,能引起动物支气管收缩,但尚未有人研究过其对人体支气管的作用。作者比较了吸入前列腺素D_2和前列腺素F2α对特殊气道通气的影响。其中包括7名正常人,平均年龄27±1岁;7例轻度过敏型哮喘患者,平均年龄26±1岁。均为不吸烟男性,在试验前4天停服任何药物。7例哮喘患者使特殊气道通气下降35%的组胺量均少于500μg/ml。在正常人量效关系研究中,前列腺素D_2仅在高
Although prostaglandin D 2 is the prostaglandin with the highest secretion of mast cells in human lungs, it can cause bronchoconstriction in animals. However, no studies have been conducted on its effects on the human bronchus. The authors compared the effects of inhaled prostaglandin D_2 and prostaglandin F2α on specific airway ventilation. Including seven normal people, the average age of 27 ± 1 years old; 7 patients with mild allergic asthma, the average age of 26 ± 1 years old. All non-smoking men stopped taking any medication 4 days before the test. The histamine levels of 35% of patients with asthma who underwent special airway ventilation were all less than 500 μg / ml. In the normal dose-effect relationship studies, prostaglandin D_2 only high