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目的：观察国产氢氯吡格雷（泰嘉）在脑血管支架成形术（CAS）围手术期应用的疗效和安全性。方法入选拟行脑血管支架成形术的患者共20例，所有患者至少于术前7 d予以国产氢氯吡格雷，75 mg/天，术后继续口服3个月，期间均合用拜阿斯匹灵肠溶片（阿司匹林）200 mg/晚。观察3个月随访期内有无心脑血管事件及药物不良反应发生。结果20例患者中，共置入支架24枚，手术成功率100%。用药后3个月与入组时相比较，FBG、LDL-C、CRP、Fg均有所下降，差异具有统计学意义（P＜0.05）；白细胞计数、血肌酐有所升高，血小板计数稍降低，血ALT、AST稍有升高，差异无统计学意义。用药后3个月平均NIHSS评分与入组时相比显著下降，差异具有统计学意义（8.64±2.22 vs 4.54±2.78，P=0.004）；3个月随访时mRS评分（1.60±0.78），大部分患者神经功能恢复良好（mRS≤2分，16/20，80%）。围手术期发生短暂性脑缺血发作（TIA）1例。术后随访期间发生肝功能轻度受损2例，皮肤瘙痒1例，无其他心脑血管事件及药物不良反应发生。结论国产氢氯吡格雷用于CAS围手术期疗效可靠，安全性良好，可以作为CAS围手术期与阿司匹林联合抗血小板治疗的药物。“,”Objective To observe safety and effectiveness of domestic hydrogen clopidogrel (Tai-jia) in perioperative patients with carotid angioplasty and stenting (CAS).Methods20 patients who would undergo CAS were enrolled in this study. All patients were given Tai-jia at a dose of 75 mg per day for at least 7 days prior to the operation, followed by 75 mg per day for 3 months. All the participants received aspirin at a dose of 75 mg during the study period. Cardio-cerebrovascular events and side effects were observed during the 3-month follow-up period.Results Of 20 patients enrolled, 24 stents were placed. The successful rate of operation was 100%. There were statistically signifi cant differences in FBG, LDL-C, CRP and Fg between the origin and end of the follow-up period (P<0.05). However, no signifi cant differences in white blood cell counts, serum creatinine, platelet counts, ALT and AST; In addition, there were statistically significant differences in NIHSS score (8.64±2.22 vs 4.54±2.78,P=0.004), and most patients recovered well at the end of the follow-up period (mRS 1.60±0.78, mRS≤2, 80%). 1 case was defi ned as TIA during the perioperative period. 2 cases of mild liver dysfunction and 1 case of itch were found during the study period. There were no cardio-cerebrovascular events and adverse drug reactions.Conclusion The safety and effectiveness of domestic hydrogen clopidogrel (Tai-jia) are satisfactory in perioperative patients with CAS, and the combination antiplatelet therapy of Tai-jia with aspirin can be used in perioperative period of CAS.