【摘 要】
：
Four new seco-dibenzocyclooctadiene lignans, kadlongilignans A-D (1-4), consisting of a rare 6,7-seco-(1), two 15,16-seco-(2 and 3) and a 9,10-seco-dibenzocyclo
【机 构】
：
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materi
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Four new seco-dibenzocyclooctadiene lignans, kadlongilignans A-D (1-4), consisting of a rare 6,7-seco-(1), two 15,16-seco-(2 and 3) and a 9,10-seco-dibenzocyclooctadiene (4) lignans, were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by spectroscopic analysis, including extensive NMR, MS and ECD (electronic circular dichroism) spectra. Compounds 3 and 4 exhibited potent inhibitory activities against NO (nitric oxide) production of LPS (lipopolysaccharide)-induced murine macrophages with the inhibition rates of 36.3％and 26.9％, respectively.
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