【摘 要】
:
Four new seco-dibenzocyclooctadiene lignans, kadlongilignans A-D (1-4), consisting of a rare 6,7-seco-(1), two 15,16-seco-(2 and 3) and a 9,10-seco-dibenzocyclo
【机 构】
:
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materi
论文部分内容阅读
Four new seco-dibenzocyclooctadiene lignans, kadlongilignans A-D (1-4), consisting of a rare 6,7-seco-(1), two 15,16-seco-(2 and 3) and a 9,10-seco-dibenzocyclooctadiene (4) lignans, were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by spectroscopic analysis, including extensive NMR, MS and ECD (electronic circular dichroism) spectra. Compounds 3 and 4 exhibited potent inhibitory activities against NO (nitric oxide) production of LPS (lipopolysaccharide)-induced murine macrophages with the inhibition rates of 36.3%and 26.9%, respectively.
其他文献
A new silver mediated aminophosphinoylation of propargyl alcohols with aromatic amines and H-phosphine oxides for the construction of α-aminophosphine oxides h
A selective ring-opening [3+2] cyclization reaction of benzo[d]isoxazoles with 2-bromo-propanamides hasbeendeveloped.Theazaoxyallylcationintermediatesareemploye
A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole. Salient feature of the work is the rapid formatio
An efficient water-based bismuth-mediated addition reaction of carbonyl compound with cyclic allylic halide was developed. The reactions proceeded smoothly in a
Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new an
In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTT assays indicated that most of th
A quinine-derived thiourea-catalyzed inter-/intramolecular Michael cycloaddition of chromone-oxindole/benzofuranone synthons with 3-substituted methylenebenzofu
In this study, various nonionic surfactants (NS) with different ethylene oxide (EO) numbers and tail lengths and its binary blends with anionic surfactants (AS)
A novel meroterpenoid, euphoractone (1), was isolated from the extracts of the roots of Euphorbiafischeriana Steud. Its structure was determined by spectroscopi