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目的:分析肿瘤患者人群中血型不规则抗体的检出频率及分布特点,为肿瘤患者的输血提供帮助。方法:对2013-01-2013-12住院的14 400例肿瘤患者应用盐水、抗人球蛋白法、聚凝胺法检测血型不规则抗体,同时鉴定出其特异性。结果:14 400例肿瘤患者中,不规则抗体阳性62例(0.43%),其中恶性肿瘤患者阳性率为0.56%(44/7854),与良性肿瘤的0.27%(18/6 546)比较,差异有统计学意义(P<0.05);女性阳性率0.65%(48/7398)高于男性0.20%(14/6 940),有输血史0.54%(42/7 750)高于无输血史30.0%(20/6 588),有妊娠1.10%(38/3 445)高于无妊娠0.25%(10/3 953),各组间比较差异均有统计学意义(均P<0.01);血型不规则抗体特异性中抗-E抗体居多,在各种肿瘤中的分布不均(P<0.05)。结论:恶性肿瘤患者不规则抗体阳性率高于良性肿瘤患者,女性患者不规则抗体阳性率与妊娠有关,输血前检测不规则抗体有利于保障临床用血,降低溶血性输血反应的发生。
OBJECTIVE: To analyze the frequency and distribution of irregular blood-type antibodies in cancer patients and to provide help for the transfusion of cancer patients. METHODS: Saline, anti-human globulin and polybrene were used to detect irregular blood-type antibodies in 14 400 cancer patients hospitalized from January 2013 to December 2013. The specificity of the antibody was also identified. Results: Of the 14 400 cancer patients, 62 (0.43%) were positive for irregular antibodies, with a positive rate of 0.56% (44/7854) for malignant tumors and 0.27% (18/6 546) for benign tumors (P <0.05). The positive rate of female was 0.65% (48/7398) higher than that of male 0.20% (14/6 940). The history of blood transfusion 0.54% (42/7 750) was higher than that of no blood transfusion 30.0% (20/6 588), with 1.10% (38/3 445) of pregnancy than 0.25% (10/3 953) of pregnancy, the difference between the two groups was statistically significant (all P <0.01); irregular blood type Antibody-specific anti-E antibodies are mostly present in various tumors (P <0.05). Conclusion: The positive rate of irregular antibody in malignant tumor patients is higher than that of benign tumor patients. The positive rate of irregular antibody in female patients is related to pregnancy. Detecting irregular antibodies before transfusion is helpful to ensure clinical blood supply and reduce hemolytic transfusion reaction.