/E.Patchen Dellinger//Ann Surg2007;245:674-683在急性重症坏死性胰腺炎发病早期,目前通常使用广谱抗生素如碳青酶烯类抗生素,以期能减少胰腺或胰周感染的发生率,但缺乏循证依据,为此作者采用双盲安慰剂随机对照研究来评估预防性静脉使用美罗培南在尚未发生感染的急性重症坏 /E.Patchen Dellinger // Ann Surg2007; 245: 674-683 In the early stages of acute severe necrotizing pancreatitis, broad-spectrum antibiotics, such as carbapenem antibiotics, are commonly used to reduce the incidence of pancreatic or peripancreatic infections , But lacking evidence-based evidence, the authors used double-blind, placebo-controlled, randomized, controlled trials to evaluate prophylactic intravenous use of Meropenem in acute, critically ill patients with no previous infection