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妊娠相关血浆蛋白-A(PAPP-A)最先是从孕妇血清中分离出来的一种与妊娠相关联的大分子糖蛋白。后来发现它是一种与胰岛素样生长因子相关的锌指超家族中的金属螯合蛋白酶。近年来,发现PAPP-A和急性冠脉综合征(ACS)关系密切,是ACS新的标记物。在不稳定的粥样斑块中大量表达,对识别不稳定斑块有着非常重要的作用。
Pregnancy Associated Plasma Protein-A (PAPP-A) is the first of a kind of pregnancy-associated macromolecular glycoprotein isolated from pregnant women’s serum. It was later found to be a metal chelating protease in the zinc finger superfamily associated with insulin-like growth factor. In recent years, PAPP-A was found to be closely related to acute coronary syndrome (ACS) and a new marker of ACS. Expressed in unstable atherosclerotic plaques, it plays a very important role in identifying unstable plaque.