AIM: To analyze the incidence of digestive system cancer in Changle of China over a 15-year period. METHODS: The datasets were presented as time-series of China-standardized annual incidence during 1988-2002. Linear regression model was used to analyze the incidence of stomach, liver, esophagus and colorectal cancers. RESULTS: Linear regression models for the time-series of stomach and esophagus cancer incidences for both men and women were statistically significant (P < 0.05); Regression models for liver cancer and for colorectal cancer were statistically significant for men (P < 0.05). CONCLUSION: The incidence rates of stomach and esophagus cancers for both men and women had down tendencies. For men, liver cancer had a down trend of the incidence and colorectal cancer had an upward trend of the incidence rate. AIM: To analyze the incidence of digestive system cancer in Changle of China over a 15-year period. METHODS: The datasets were presented as time-series of China-standardized annual incidence during 1988-2002. Linear regression model was used to analyze the incidence of stomach, liver, esophagus and colorectal cancers. RESULTS: Linear regression models for the time-series of stomach and esophagus cancer incidences for both men and women were statistically significant (P <0.05); Regression models for liver cancer and for colorectal cancer The statistically significant for men (P <0.05). CONCLUSION: The incidence rates of stomach and esophagus cancers for both men and women had down tendencies. For men, liver cancer had a down trend of the incidence and colorectal cancer had an upward trend of the incidence rate.