双氟苯柳酸(Diflunisal)是由美国Merck公司从约500个化合物中筛选得到的一种效力、安全性和作用时间均优于乙酰水杨酸(阿司匹林)的水杨酸衍生物,商品名‘Dolobid’,化学名为2’,4’-双氟-4-羟基-3-二苯基羧酸。大鼠药理实验表明,本品镇痛效力为阿司匹林的10倍,消炎作用时间比阿司匹林长8～12倍。它是一种前列腺素合成酶抑制剂,但并不象阿司匹林和消炎痛 Diflunisal is a salicylic acid derivative that is screened from about 500 compounds by Merck Company of the United States for its potency, safety, and duration of action over acetylsalicylic acid (aspirin) ’Dolobid’, chemical name is 2 ’, 4’-difluoro-4-hydroxy-3-diphenyl carboxylic acid. Pharmacological experiments in rats show that the analgesic efficacy of this product is 10 times that of aspirin, anti-inflammatory effect than aspirin 8 to 12 times longer. It is a prostaglandin synthetase inhibitor, but not as aspirin and indomethacin