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国家食品药品监督管理局第31期《药品不良反应信息通报》警示,异维A酸口服剂可导致罕见的严重皮肤损害。异维A酸是维生素A的衍生物,用于治疗痤疮及角化异常性疾病。今年3月,欧洲药品管理局对异维A酸导致的皮肤损害进行评估后认为,异维A酸与多形性红斑之间的因果关系存在“充足的证据”。
State Food and Drug Administration No. 31 “Adverse Drug Reaction Bulletin” warned that isotretinoin oral agent can cause rare serious skin damage. Isotretinoin is a derivative of vitamin A for the treatment of acne and keratoses. In March of this year, the European Medicines Agency evaluated the skin lesions caused by isotretinoin and found that there is “sufficient evidence” for the causal link between isotretinoin and erythema multiforme.