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目的探讨医院感染假丝酵母菌病的毒力因素,为研究医院感染假丝酵母菌病的致病性提供依据。方法收集2010年3月1日-2013年6月30日医院感染假丝酵母菌病共98例患者,依照EORTC/MSG专家共识中对假丝酵母菌病的分类标准,将白色假丝酵母菌感染病例分为深部器官感染组及皮肤黏膜感染组;通过分析磷脂酶活性及溶血性对不同种类假丝酵母菌作毒力因子比较,并进一步比较深部器官感染及皮肤黏膜感染白色假丝酵母菌的毒力;采用SPSS17.0系统对数据进行统计分析。结果 98例假丝酵母菌病构成以白色假丝酵母菌病72例为主,占73.5%,不同种类假丝酵母菌的Pz指数及溶血指数比较差异无统计学意义;72例白色假丝酵母菌病标本中深部器官感染组52例占72.2%,皮肤黏膜感染组20例占27.8%;深部器官感染组白色假丝酵母菌的Pz值及溶血指数均高于皮肤黏膜感染组,差异有统计学意义(P<0.05)。结论不同种类假丝酵母菌的磷脂酶及溶血性毒力无差异,白色假丝酵母菌感染侵袭的部位与其磷脂酶及溶血性毒力相关。
Objective To investigate the virulence factors of Candida infection in hospital and provide the basis for studying the pathogenicity of Candida infection in hospital. Methods A total of 98 hospitalized patients with Candida Infectious Diseases were collected from March 1, 2010 to June 30, 2013. According to the classification criteria of Candida albicans in the EORTC / MSG expert consensus, Candida albicans Infected cases were divided into deep organ infection group and skin mucosal infection group; By analyzing the phospholipase activity and hemolytic toxicity of different types of Candida compared, and further comparison of deep organ infection and skin mucosa infection Candida albicans Virulence; using SPSS17.0 system for statistical analysis of the data. Results The results showed that 72 cases of Candida albicans were found in 98 cases of Candida, accounting for 73.5%. There was no significant difference in Pz index and hemolysis index between Candida albicans and Candida albicans 52 cases of deep organ infection in the disease specimens accounted for 72.2%, 20 cases of skin and mucosal infection accounted for 27.8%; deep organ infection group Candida albicans Pz value and hemolysis index were higher than the skin mucosal infection group, the difference was statistically significant Significance (P <0.05). Conclusion There is no difference in the phospholipase and hemolytic virulence between Candida albicans and Candida albicans infection and their phospholipase and hemolytic virulence.