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目的:探讨青年乳腺癌(年龄≤35岁)的临床特点及预后。方法:回顾性分析青年乳腺癌的临床特点及预后,并随机抽取同期非青年乳腺癌58例作为对照,比较两组患者临床特点及预后的差异。结果:60例中病程为10天￣35个月;病理分型以浸润性癌为主,占93%(56/60);39例有腋下淋巴结转移,占65.1%;有8例为妊娠、哺乳期患者;随访率100%,青年组3年、5年生存率分别为76.4%、55.7%;而对照组分别为92.7%、77.1%。青年组根治术后3年、5年复发转移率分别为36%、58%;而对照组分别为14.9%、33.9%,两组预后存在明显差异(P<0.05)。结论:青年乳腺癌病程长,以浸润性癌为主,淋巴结转移率高,加之合并妊娠哺乳,预后较差。
Objective: To investigate the clinical features and prognosis of young breast cancer (≤35 years old). Methods: The clinical features and prognosis of young breast cancer were retrospectively analyzed. Fifty-eight non-young breast cancer patients were randomly selected as control group. The clinical characteristics and prognosis of the two groups were compared. Results: The course of disease in 60 cases was 10 days to 35 months. The pathological type was mainly infiltrating carcinoma, accounting for 93% (56/60), 39 cases had axillary lymph node metastasis (65.1%), and 8 cases were pregnancy , Breast-feeding patients. The follow-up rate was 100%. The 3-year and 5-year survival rates of youth group were 76.4% and 55.7% respectively, while those of the control group were 92.7% and 77.1% respectively. In the youth group, the 5-year recurrence and metastasis rates were 36% and 58% respectively after 3 years of radical operation, while those in the control group were 14.9% and 33.9% respectively. There was significant difference between the two groups in prognosis (P <0.05). Conclusion: The long duration of breast cancer in young patients is mainly based on invasive carcinoma with high rate of lymph node metastasis. Combined with pregnancy and lactation, the prognosis is poor.