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顺式二氯二氨合铂(Cis-Dichlorodi-amine-platinum,简称顺铂)是一类新型化学合成的二价铂络合物。自1969年Rosenb-erg等人首先发现其抗肿瘤活性以来,己广泛试用于各种癌症治疗。临床资料表明它具有广谱的抗癌活性,但也有严重的肾脏毒性,且已成为临床上进一步广泛使用的重要限制因素。有关肾毒的病理变化,国外己有不少报告,但尚未见到电镜观察的系统资料。本文就国产顺铂对大鼠肾毒性的超微结构变化作一较详细的观察。
Cis-Dichlorodi-amine-platinum (cis-platinum) is a new class of chemically synthesized bivalent platinum complexes. Since 1969 Rosenb-erg, who first discovered its anti-tumor activity has been widely used in a variety of cancer treatment. Clinical data show that it has a broad spectrum of anticancer activity, but also has serious renal toxicity and has become an important limiting factor for further widespread use in the clinic. Regarding the pathological changes of nephrotoxicity, many reports have been made abroad, but systematic data of electron microscope observation have not yet been seen. This article on the domestic cisplatin nephrotoxicity ultrastructural changes in rats made a more detailed observation.