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脊髓损伤是主动脉手术的主要并发症之一 ,旨在研究卡托普利对家兔肾上主动脉横夹所致脊髓损伤的保护作用。方法 :家兔 2 4只 ,随机分为正常对照组 (A)、缺血组 (B)和卡托普利组 (C)。肾上横夹腹主动脉 30min后松开 ,C组于横夹前 10min静注卡托普利 0 .5mg·kg-1继以 0 .15mg·kg-1·h-1持续输注至松开前 10min。余 2组静注等容量生理盐水 ,B组其它操作同C组 ,A组不夹闭。测定给药前 (C-10 )、松夹前 (C3 0 )和松夹后 3h(R3h)的血浆丙二醛 (MDA)浓度和超氧化物歧化酶 (SOD)活性 ,术后观察脊髓形态变化 ,并测定脊髓组织MDA含量。结果 :卡托普利可明显改善脊髓形态学改变 ;卡托普利可明显降低血中及组织中MDA含量 ,但不保护SOD活性 ;脊髓组织MDA含量与形态学改变有明显正相关。结论 :卡托普利对家兔肾上主动脉横夹所致脊髓损伤有良好保护作用 ,其机制与抗氧化作用有关。
Spinal cord injury is one of the main complications of aortic surgery, and aims to study the protective effect of captopril on spinal cord injury caused by transverse renal artery occlusion in rabbits. Methods: Twenty four rabbits were randomly divided into normal control group (A), ischemic group (B) and captopril group (C). After the renal graft transverse abdominal aorta 30min release, C group 10min before the transverse clamp captopril 0 .5mg · kg-1 followed by 0.15mg · kg-1 · h-1 continuous infusion to pine Open the first 10min. The remaining two groups of intravenous infusion of equal volume of saline, other operations in group B with the C group, A group is not closed. The levels of plasma malondialdehyde (MDA) and superoxide dismutase (SOD) were measured before administration (C-10), before the pinecone clamp (C3 0) and after 3 hours (R3h) Changes and determination of spinal cord tissue MDA content. Results: Captopril significantly improved spinal morphological changes; captopril significantly reduced MDA content in blood and tissue, but did not protect SOD activity; spinal cord tissue MDA content and morphological changes were significantly positively correlated. CONCLUSION: Captopril has a good protective effect on spinal cord injury induced by transverse adrenal artery in rabbits. The mechanism is related to the anti-oxidation effect.