据日媒报道,日本受托研究机构KRI发现米酒和纳豆具有改善“时差障害”效果。KRI确立和验证了调节生物钟的核内受容体(REV-ERBα)配体的简易评价方法。其主要原理是开发了接触到相应配体发荧光的酵母细胞,添加样品放置一晚上第二天测量荧光,根据荧光强度大小评估配体的有效性。该评价方法所需时间段,成本低。 According to Japanese media reports, KRI, Japan’s trusted research institute, found that rice wine and natto have the effect of improving “jet lag”. KRI established and validated a simple method for evaluating the nuclear receptors (REV-ERBα) that regulate the circadian clock. The principle is to develop yeast cells that fluoresce when exposed to the corresponding ligands. Fluorescence is measured on the next day after the sample is added, and the effectiveness of the ligand is assessed on the basis of the intensity of the fluorescence. The time and cost of this evaluation method is low.