有些药物多次应用可诱导肝微粒体酶的活性增加(酶促作用),从而导致其他一些药物代谢加速、药效减弱。例如,苯巴比妥钠能够加速口服抗凝药的代谢,所生两药合用时,应适当增加口服抗凝药的剂量,而停用苯巴比妥钠后,即应酌减口服抗凝药的剂量,以防止出现自发性出血。值得注意的还有:巴比妥类可促进香豆素类抗凝药、洋地黄毒甙、苯妥因钠、保泰松、皮质激素、强力霉素、雌激素、VitD及甲磺丁脲的代谢;苯妥因钠促进氢化可 The repeated use of some drugs can induce increased activity of liver microsomal enzymes (enzymatic), leading to accelerated metabolism of some other drugs, efficacy weakened. For example, phenobarbital sodium can accelerate the metabolism of oral anticoagulants, the combined use of the two drugs should be appropriate to increase the dose of oral anticoagulant, and disable the phenobarbital sodium, it should be discretionary oral anticoagulation The dose of medicine to prevent spontaneous bleeding. It is also worth noting that barbiturates promote coumarin anticoagulants, digoxigenin, phenytoin sodium, phenylbutazone, corticosteroids, doxycycline, estrogen, VitD and metoxic The metabolism of phenytoin can promote hydrogenation