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目的回顾性分析冠心病合并糖尿病死亡患者代谢异常特征。方法采用病例对照法,选取2006年11月-2016年3月近十年间在北京安贞医院心内科住院的冠心病合并糖尿病死亡患者52例为病例组,冠心病无糖尿病死亡患者52例为对照组。所有入选患者以心血管疾病为首要死因且病案资料完整,组间性别及年龄均匹配。比较一般资料及代谢性指标如总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、空腹血糖、糖化血红蛋白、血尿酸等。结果冠心病合并糖尿病死亡患者冠心病病程、吸烟史、住院次数及血脂异常与对照组相比,差异有统计学意义(P<0.05);空腹血糖、糖化血红蛋白与对照组相比,差异有统计学意义(P<0.01);血脂代谢指标中仅甘油三酯水平与对照组相比,差异有统计学意义(P=0.01)。结论血糖及甘油三酯水平升高是冠心病合并糖尿病死亡患者的主要代谢异常特征。
Objective To retrospectively analyze the metabolic abnormalities in patients with coronary heart disease and diabetes mellitus. Methods A case-control study was conducted in 52 cases of coronary heart disease with diabetes mellitus who were hospitalized in the Department of Cardiology, Anzhen Hospital, Beijing from November 2006 to March 2016. A total of 52 patients died of diabetes without coronary heart disease group. All selected patients with cardiovascular disease as the leading cause of death and complete medical records, gender and age groups were matched. Comparison of general information and metabolic indicators such as total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, fasting blood glucose, glycosylated hemoglobin, blood uric acid and so on. Results Compared with the control group, the duration of coronary heart disease, smoking history, number of hospitalizations and dyslipidemia in patients with coronary heart disease and diabetes mellitus were significantly different (P <0.05). There was statistical difference in fasting blood glucose and glycosylated hemoglobin compared with the control group (P <0.01). Compared with the control group, triglyceride level in lipid metabolism index was significantly different (P = 0.01). Conclusion The elevated blood glucose and triglyceride levels are the major metabolic abnormalities in patients with coronary heart disease and diabetes mellitus.