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目的 :研究晚期胰腺癌病人抗凝、纤溶功能的变化 ,并探讨其临床意义。方法 :以AT ⅢA %、AT ⅢAg、PC :A反映抗凝功能 ,PLg、tpA :A、PAI :A、FDP等 4项指标反映纤溶功能 ,并与正常人群对照。结果 :在晚期胰腺癌组 ,AT ⅢA %降低 (P <0 0 1) ,而AT ⅢAg、PC :A升高 (P <0 0 1)。PLg、tpA :A、PAI :A均降低 (P <0 0 1) ,而FDP明显升高 (P <0 0 0 1)。结论 :晚期胰腺癌患者存在明显的抗凝、纤溶异常 ,原因与胰腺癌本身有关 ,如不加以正确处理 ,将使病情恶化
Objective: To study the changes of anticoagulant and fibrinolytic function in patients with advanced pancreatic cancer and to explore its clinical significance. Methods: The anticoagulant function was reflected by AT Ⅲ A%, AT Ⅲ Ag and PC: A. The indexes of PLg, tpA: A, PAI: A and FDP reflected the fibrinolytic function and were compared with the normal population. Results: In the group of advanced pancreatic cancer, AT Ⅲ A% decreased (P 0 01) and AT Ⅲ Ag and PC A increased (P 0 01). PLg, tpA: A, PAI: A decreased (P <0.01) and FDP increased significantly (P <0.01). Conclusion: There are obvious anticoagulation and fibrinolytic abnormalities in patients with advanced pancreatic cancer. The reasons are related to pancreatic cancer itself. If not properly treated, the disease will worsen