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目的探究结节性胃炎患儿幽门螺杆菌耐药状况。方法从我院于2011年6月至2014年6月收治的诊断为结节性胃炎的100例患儿作为此次研究对象,对胃窦黏膜菌株培养后,进行耐药试验并比较不同年龄、不同病理程度患儿感染幽门螺杆菌概率。结果 100例患儿胃镜下检查结果为:56例单纯结节性胃炎,23例结节性胃炎合并十二指肠球炎,21例结节性胃炎合并十二指肠球部溃疡;97例患儿尿素酶试验为阳性,3例阴性;胃黏膜培养结果显示,有55例患儿为阳性;5~6岁患儿有1例感染,7~12岁患儿有18例感染,12~16岁患儿有36例感染,组间数据比较无统计学差异(χ2=0.154,P>0.05);100例结节性胃炎患儿中有82例(82%)为中-重度炎症,有47例(57.3%)感染幽门螺旋杆菌,而非中-重度炎症患儿有18例(18%),其中有8例(44.4%)感染幽门螺旋杆菌,感染幽门螺杆菌数据比较有统计学意义(χ2=132.7,P<0.05);幽门螺杆菌对甲硝唑的耐药性最高(27株,49.1%),其次是克拉霉素(19株,34.5%),克拉霉素联合甲硝唑(12株,21.8%)位列第三,耐药性最低的是左氧氟沙星,且其药物的敏感度与阿莫西林相同(51株,92.7%),位列敏感度第一。结论 结节性胃炎患儿幽门杆菌对甲硝唑、克拉霉素的耐药率较高,对左氧氟沙星和阿莫西林的耐药率较低。
Objective To investigate the drug resistance of Helicobacter pylori in children with nodular gastritis. Methods A total of 100 children with nodular gastritis diagnosed in our hospital from June 2011 to June 2014 were selected as the study objects. After the gastric mucosa of gastric antrum was cultured, drug resistance was tested and compared with different age, Different pathological levels of children infected with Helicobacter pylori probability. Results The results of gastroscopy in 100 cases were as follows: 56 cases of simple nodular gastritis, 23 cases of nodular gastritis with duodenal inflammation, 21 cases of nodular gastritis with duodenal ulcer and 97 cases Children urease test was positive, 3 cases were negative; gastric mucosa culture results showed that 55 cases of children were positive; 5 to 6-year-old children with 1 case of infection, 7 to 12-year-old children 18 cases of infection, 12 ~ There were 36 cases of infection in 16-year-old children. There was no significant difference between the two groups (χ2 = 0.154, P> 0.05); 82 cases (82%) of 100 cases of nodular gastritis were moderate- 47 (57.3%) were infected with Helicobacter pylori, but 18 (18%) were non-moderate-severe infants, of which 8 (44.4%) were infected with Helicobacter pylori and the data of Helicobacter pylori infection were statistically significant (χ2 = 132.7, P <0.05). H.pylori had the highest resistance to metronidazole (27 strains, 49.1%), followed by clarithromycin (19 strains, 34.5%), clarithromycin combined with metronidazole (12 strains, 21.8%) ranked the third. Levofloxacin with the lowest drug resistance was the same as the amoxicillin (51 strains, 92.7%) with the highest sensitivity. Conclusions Helicobacter pylori in children with nodular gastritis have higher resistance rates to metronidazole and clarithromycin and lower resistance rate to levofloxacin and amoxicillin.