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目的 :研究、摸索治疗脑转移性肿瘤的有效方法。方法 :采用替尼泊苷 甲环亚硝脲 (VM2 6 MeCCNU)的组合化疗 ,结合传统的中医辩证论治 ,部分病例同时进行g刀或直线加速器照射等治疗。结果 :症状改善及消失率为84 .2 1 % ;影像学 (CT或MRI)复查 :CR 4例 ( 1 2 .5% ) ,PR 9例 ( 2 8.1 3 % ) ,NR 1 4例 ( 43 .75% ) ,PD 5例 ( 1 5.63 % ) ,有效率 4 0 .63 % ;存活时间少于 6个月者 7例 ( 2 3 .3 % ) ,超过 6个月者 2 3例 ( 76.67% ) ,其中超过 1年者 1 5例 ,超过 1 .5年者 1 1例 ,超过二年者 8例 ,平均存活时限 1 8.6月。结论 :以替尼泊苷 甲环亚硝脲联合化疗为主 ,辅以中药及放疗是治疗脑转移性瘤的有效治疗组合 ,其治疗效果优于文献报告。
Objective: To study and explore effective methods for the treatment of brain metastases. Methods: The combined chemotherapy of tenniposide and mefloxacin (VM2 6 MeCNNU) combined with the traditional dialectical treatment of traditional Chinese medicine (TCM) was adopted. In some cases, g-knife or linear accelerator irradiation was performed simultaneously. Results: The symptom improvement and disappearance rate was 84.21%. CT or MRI was performed in 4 cases (12.5%), PR 9 cases (8.131%) and NR 1 4 cases (43 cases) .75%), PD 5 cases (5.63%), the effective rate was 40.63%, 7 cases (2.3.3%) had survival time less than 6 months, 23 cases (76.67% %), Of which more than 1 year in 15 cases, more than 1.5 years in 11 cases, more than two years in 8 cases, the average survival time of 18.6 months. CONCLUSION: The combination of teniposide and carboplatin with nitrosourea and chemotherapy plus radiotherapy is an effective therapeutic combination for the treatment of metastatic brain tumors. The therapeutic effect is better than that reported in the literature.