The synthesized C-phycocyanins(C-PCs)doped silica biomaterials were charac-terized by the SEM and BET surface area analysis measurement.The morphology of C-PCs doped silica biomaterials indicates that the surface of the silica cluster is formed by a great number of silica particles with an average size of between 30 and 40 nm.Silica itself is a porous structure with the av-erage pore diameter of 2.95 nm.Pores with their diameter less than 5 nm account for 84.07%.In ad-dition,the C-PCs can be utilized as a fluorescent protein probe to monitor influence of the protein encapsulation and to study matrix and protein interaction and stability of protein in silica matrix.Ap-plication of protein encapsulation silica materials requires biomolecules to keep bioactivity and sta-bility on potentially unfavorable industrial conditions.The C-PCs in solution or in silicate matrix ir-radiated by ultraviolet ray can result in photobleaching,whereas the protein in the silica is less affected.The measured photodamage rate constant of C-PCs in buffer solution is 25 times faster than that of C-PCs in silica matrix.However,the lifetime of C-PCs in silica matrix or phosphate buffer is unaf-fected.These studies suggest that entrapment of C-PCs into silica matrixes not only can maintain their biological activity but also noticeably improve their photostability.