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目的:对比观察左乙拉西坦与托吡酯治疗癫痫的有效性与安全性,同时做出客观评价。方法:对2012年3月至2014年3月我院儿科门诊诊治的癫痫患儿共68例纳入观察对象的范围,根据各自用药的不同,分成对照组与观察组进行比较;其中观察组患儿所用药物为左乙拉西坦,对照组使用托吡酯,维持治疗6个月后,对两组治疗有效率进行统计比较,同时观察患儿治疗中出现的不良反应症状,同样进行比较评价。结果:持续治疗半年后,两组患者临床症状表现均得到好转,病情逐渐稳定与恢复,但从所记录的数据上来看,观察组有效率显著高于对照组,且差异P<0.05,具备统计学意义;两组患儿在治疗中有少数出现了不良反应,但症状较轻,恢复较快,可见该两种药物的安全性较高。结论:左乙拉西坦与托吡酯对于小儿癫痫均具有不错的疗效,且安全性比较高,临床用要是要注意合理选择。
OBJECTIVE: To compare the efficacy and safety of levetiracetam with topiramate in the treatment of epilepsy, and to make an objective evaluation. Methods: A total of 68 children with epilepsy from March 2012 to March 2014 in our pediatric outpatient department were enrolled in the study. The patients were divided into the control group and the observation group according to their different medication. The patients in the observation group The drug used was levetiracetam, and the control group was given topiramate. After 6 months of maintenance treatment, the treatment efficiency of the two groups were statistically compared, and the symptoms of adverse reactions in the treatment of children were also observed. Results: Six months after continuous treatment, the clinical symptoms of both groups improved, and the condition gradually stabilized and recovered. However, the observed data showed that the observation group was significantly more effective than the control group (P <0.05) Learning significance; two groups of children in the treatment of a small number of adverse reactions, but the symptoms are lighter, faster recovery, showing the higher safety of the two drugs. CONCLUSION: Levetiracetam and topiramate have a good effect on pediatric epilepsy, and the safety is relatively high, so it is necessary to pay attention to the rational choice in clinical use.