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目的:应用区域阻抗法测定慢性阻塞性肺疾病(COPD)患者的肺血流灌注及肺通气分布的变化,与放射性核素肺显像方法比较,探讨肺区域阻抗方法的临床应用价值。方法:测定对象为18例中重度COPD患者,均为男性,平均年龄63.8岁,应用肺区域阻抗法及放射性核素法,分别测定肺血流灌注及肺通气的分布。结果:本研究发现肺区域阻抗法在测定肺血流灌注分布方面,仅在左下肺区域高于核素法测得的数值(P<0.05),余肺区测定结果相近,无显著差异。在肺通气的测定方面,阻抗法所得数值与核素法测得的数值有一定的不同,在左上、右上区域高于核素法测得的数值,在左中肺区测得的数值低于核素法测得的数值(P<0.05),余肺区测定结果相近,无显著差异。结论:虽然目前区域阻抗方法暂不能取代放射性核素的测定,但作为一种辅助手段,可简便、快速了解肺内的通气、血流等生理病理改变。
Objective: To determine the changes of pulmonary perfusion and pulmonary ventilation in patients with chronic obstructive pulmonary disease (COPD) by using the regional impedance method and to compare with the methods of radionuclide lung imaging to explore the clinical value of pulmonary impedance. Methods: Twenty-eight patients with moderate-to-severe COPD were enrolled in this study. The mean age was 63.8 years old. Pulmonary perfusion and pulmonary ventilation were measured by pulmonary area impedance and radionuclide methods respectively. Results: In this study, we found that the lung area impedance method was superior to the nuclide method in determining the distribution of pulmonary perfusion only in the left lower lung area (P <0.05) and in the remaining lung area with similar results. In the determination of pulmonary ventilation, the value obtained by the impedance method and the nuclide method has some differences between the value measured in the upper left and upper right area higher than the nuclide method measured values in the left lung area measured values lower than Nuclide method measured values (P <0.05), the rest of the lung area measured results were similar, no significant difference. Conclusion: Although the current regional impedance method can not temporarily replace the determination of radionuclides, it can be used as an adjunct to easily and quickly understand the physiological and pathological changes of the lung such as ventilation and blood flow.