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应用 HID/AB 组织化学染色法,CEA 免疫组化及凝集素亲合组织化学方法对56例大肠息肉研究发现:41例肿瘤性息肉(简称腺瘤)中,HID/AB 粘蛋白染色3例出现唾液酸粘蛋白,且为中、重度不典型增生,而3例化生性息肉有2例显示唾液酸粘蛋白着色。伴有轻、中、重度不典型增生的腺瘤 CEA 阳性率分别为75%、84.6%和100%。WGA、DBA、UEA 和 PNA4种凝集素染色在腺瘤和非肿瘤性息肉间无明显差别。但轻、中和重度不典型增生的腺瘤 PNA 阳性率则分别高达60%、69.2%和100%。化生性息肉3例 PNA 染色均阳性。因此认为唾液酸粘蛋白、CEA 和与 PNA 结合的糖蛋白可能为癌变高发群的生物学标记,且化生性息肉与癌发生的关系值得重视。
Using HID/AB histochemical staining, CEA immunohistochemistry and lectin affinity histochemistry for 56 cases of colorectal polyps: 41 cases of neoplastic polyps (referred to as adenoma), HID/AB mucin staining appeared in 3 cases Sialic mucins were moderately and severely dysplastic, while 2 of 3 metaplastic polyps showed sialo mucin staining. The positive rates of CEA in adenomas with mild, moderate and severe dysplasia were 75%, 84.6%, and 100%, respectively. WGA, DBA, UEA, and PNA4 lectin staining showed no significant differences between adenomas and non-neoplastic polyps. However, the PNA positive rates of adenomas with mild, moderate, and severe dysplasia were as high as 60%, 69.2%, and 100%, respectively. 3 cases of metaplastic polyps were positive for PNA staining. Therefore, it is considered that sialomucin, CEA, and glycoprotein bound to PNA may be biological markers of high cancerous population, and the relationship between metaplastic polyps and carcinogenesis is worthy of attention.