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目的:比较维族与汉族乳腺癌患者的临床病理信息,旨在了解两民族之间乳腺癌临床病理特征的差异。方法:收集汉族病例407例,维族病例250例,对临床病理资料、,应用免疫组化En Vision两步法检测ER、PR、Her-2、BRCA1进行对比分析。结果:汉族及维族乳腺癌患者的年龄、淋巴结转移情况无统计学差异(P>0.05),汉族及维族患者乳腺癌的肿瘤大小、肿瘤组织学分级、ER、PR、Her-2及BRCA1的表达有统计学差异(P<0.05),维汉民族间三阴性乳腺癌的比例有显著统计学差异(P=0.0000)。维汉民族三阴性乳腺癌与BRCA1的表达存在相关性。结论:维汉民族间乳腺癌的临床病理特征存在差异,维族患者三阴性乳腺癌明显多于患者患者,维汉民族患者三阴性乳腺癌均与BRCA1基因突变有关。
Objective: To compare the clinicopathological features of Uygur and Han patients with breast cancer, and to understand the differences between the two ethnic groups in clinicopathological features of breast cancer. Methods: A total of 407 Han cases and 250 Uygur cases were collected. Clinicopathological data were analyzed by immunohistochemical En Vision two-step method to detect ER, PR, Her-2 and BRCA1. Results: There was no significant difference in age and lymph node metastasis between Han and Uighur breast cancer patients (P> 0.05). The tumor size, histological grade, ER, PR, Her-2 and BRCA1 expression in breast cancer patients There was a significant difference (P <0.05). The proportion of tri-negative breast cancer among ethnic groups was significantly different (P = 0.0000). There are correlations between the expression of BRCA1 and the triple negative breast cancer in Han and Uygur nationality. Conclusion: The clinical and pathological features of Breast cancer among ethnic groups are different. The number of triple negative breast cancer in Uygur nationality patients is significantly higher than that in patients. The triple negative breast cancer patients in Uygur and Han nationality are all associated with the mutation of BRCA1 gene.