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目的探究小剂量丙戊酸与拉莫三嗪联合治疗癫痫的临床疗效。方法选择2014年4月-2015年4月在我院治疗的64例癫痫患者,按照随机分配原则分成对照组与观察组,每组32例患者。对照组的治疗采用丙戊酸单独给药,观察组应用小剂量丙戊酸与拉莫三嗪联合治疗,对治疗后两组患者临床疗效和不良反应情况进行分析比较。结果观察组治疗总有效率93.5%,显著高于对照组治疗总有效率63.0%,差异有统计学意义(P<0.05)。观察组不良反应发生情况少。结论在癫痫的药物治疗中应用小剂量丙戊酸与拉莫三嗪联合法治疗效果显著,不良反应发生较少,可在临床中推广应用。
Objective To investigate the clinical efficacy of low dose valproic acid combined with lamotrigine in the treatment of epilepsy. Methods Sixty-four patients with epilepsy who were treated in our hospital from April 2014 to April 2015 were divided into control group and observation group according to random distribution principle, with 32 patients in each group. The control group treated with valproic acid alone, the observation group with a small dose of valproic acid and lamotrigine combined treatment, the two groups of patients after treatment clinical efficacy and adverse reactions were analyzed and compared. Results The total effective rate of the observation group was 93.5%, significantly higher than that of the control group 63.0%, the difference was statistically significant (P <0.05). Observation group adverse reactions occurred less. Conclusions In the treatment of epilepsy with low dose of valproic acid combined with lamotrigine significant effect, fewer adverse reactions, which can be widely used in clinical practice.