研究表明 ,国产奥美拉唑钠在 5.6～ 3 5mg· kg-1剂量下 ,对小鼠水浸应激性溃疡的形成有显著的抑制作用 ,溃疡形成的抑制率为 54%～ 82 % ;在 3 .5～ 7mg· kg-1剂量下 ,对幽门结扎型大鼠胃溃疡模型的形成具有显著的抑制作用 ,溃疡形成的抑制率为 89%～ 99%。由此表明 ,国产奥美拉唑钠与进口奥美拉唑钠的抗溃疡作用强度基本一致。 The results showed that domestic omeprazole sodium had a significant inhibitory effect on the formation of water stress ulcer in mice at a dose of 5.6-3.5 mg · kg-1, and the inhibitory rate of ulcer formation was 54% -82%. The dose of 3.5-7mg · kg-1 significantly inhibited the formation of gastric ulcer model in rats with pyloric ligation, and the inhibition rate of ulcer formation was 89% -99%. This shows that domestic omeprazole sodium and imported omeprazole sodium antiulcer activity intensity is basically the same.