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Objective: To study the effect of Astragalus(As) on left ventricular collagen remodeling after myocardial infarction in rats. Methods: Myocardial collagen (MC) and ratio of myocardial collagen type Ⅰ and Ⅲ in rat models of myocardial infarction treated with Astragalus injection were determined and compared with those in sham operated rats and in captopril(CAP) treated rats. Results: MC and ratio of MC Ⅰ/Ⅲ of non infarcted region in the myocardial infarction rats was higher than that in the sham group. Both AS and CAP could restrain the ascending trend of these parameters.Conclusion: Astragalus is effective in lowering the elevation of MC after infarction and changing the MC Ⅰ/Ⅲ ratio, therefore, is beneficial to improve the systolic and diastolic function of left ventricle after acute myocardial infarction.
Objective: To study the effect of Astragalus(As) on left ventricular collagen remodeling after myocardial infarction in rats. Methods: Myocardial collagen (MC) and ratio of myocardial collagen type I and III in rat models of myocardial infarction treated with Astragalus injection were determined And compared with those in sham operated rats and in captopril(CAP) treated rats. Results: MC and ratio of MC I/III of non infarcted region in the myocardial infarction rats was higher than that in the sham group. Both AS and CAP could Restrain the ascending trend of these parameters.Conclusion: Astragalus is effective in lowering the elevation of MC after infarction and changing the MC I/III ratio, therefore, is beneficial to improve the systolic and diastolic function of left ventricle after acute myocardial infarction.