Objective:To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric medicine.Methods:Roth sexes of adult albino rats(n=25) were used in this study and another group(n=30) were subjected to acute toxicity test(LD_(50)) of the plant extract.For the LD_(50),three randomized groups of 5 rats were first treated with 10,100,1 000 mg/kg body weight(bw),orally.This w as followed by a second treatment of 1500,3000,and 5 000 mg/kg bw of the leaf extract with continual monitoring of the animals for mortality or non-mortality.Incision wounds(1.3cm) were created on the skin of five groups of 5 rals using surgical blade under anesthesia.The first group was topically treated with petroleum jelly alone,group 2 was topically applied 400 mg/mL w/v of the reference drug,Neobaein,while group 3-5 were topically treated with 5-50 mg/mL w/v of the plant extract,respectively.Results:The percentage yield of the extract was 49.80%w/w dry matter.The phytochemical analysis revealed several bioactive constituents including glycosides,tannins,alkaloids,perpenoids.saponins,steroids,proteins,and carbohydrates.The LD_(50) was beyond our experimental limit and was not determined.Increased concentrations(5,20,and 50mg/mL w/v) of the extract had significant(ANOVA,P<0.05) healing effect on the incision wounds giving rise to 125%-140% while treatmentawith Neobacin resulted in 150% healing effect on the third treatment regimen compared to the control(100%).Conclusions:These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity,substantiating its use as a wound healer in folkloric medicine. Objective: To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric medicine. Methods: Roth sexes of adult albino rats (n = 25) were used in this study and another group (n = 30) were subjected to acute toxicity test ( LD 50) of the plant extract. For the LD 50, three randomized groups of 5 rats were first treated with 10, 100, 1000 mg / kg body weight (bw), orally. This w followed was followed by a second treatment of 1500, 3000, and 5 000 mg / kg bw of the leaf extract with continual monitoring of the animals for mortality or non-mortality.Incision wounds (1.3 cm) were created on the skin of five groups of 5 rals using surgical blade under anesthesia.The first group was topically treated with petroleum jelly alone, group 2 was topically applied 400 mg / mL w / v of the reference drug, Neobaein, while group 3-5 were topically treated with 5-50 mg / mL w / v of the plant extract, respectively. Results: The percentage yield of the extract was 49.80% w / w dry matter. The phytochemical analysis revealed several bioactive constituents including glycosides, tannins, alkaloids, perpenoids.saponins, steroids, proteins, and carbohydrates.The LD 50 was beyond our experimental limit and was not determined. established concentrations (5,20 and 50 mg / mL w / v (ANOVA, P <0.05) healing effect on the incision wounds giving rise to 125% -140% while treatmentawith Neobacin resulted in 150% healing effect on the third treatment regimen compared to the control (100%). Conclusions: These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity, substantiating its use as a wound healer in folkloric medicine.