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目的:研究足部反射区按摩对慢性非细菌性前列腺炎患者前列腺液中TNF-α、IL-8的影响。方法:采用随机、对照的方法,选取慢性非细菌性前列腺炎患者96例,分为两组,即治疗组为足部反射区按摩(“肾”、“输尿管”、“膀胱”、“前列腺”、“睾丸”)加前列通瘀胶囊、对照组为前列通瘀胶囊,每组各48例。经过1个疗程(4周)治疗后,观察2组患者前列腺液中TNF-α、IL-8水平的变化。结果:治疗组和对照组患者前列腺液中TNF-α治疗前的平均值分别为(69.36±12.65)pg/mL和(70.49±7.25)pg/mL,差异无统计学意义(P>0.05),治疗后分别下降为(54.04±11.08)pg/mL和(59.15±8.38)pg/mL,两组治疗前后差异有统计学意义(P<0.05)。治疗组较对照组有更明显改善,差异有统计学意义(P<0.05)。两组患者前列腺液中IL-8治疗前的平均值分别为(8.03±1.45)ng/mL和(7.94±1.51)ng/mL,差异无统计学意义(P>0.05),治疗后分别下降为(3.76±1.73)ng/mL和(4.42±1.45)ng/mL,两组治疗前后差异有统计学意义(P<0.05)。治疗组较对照组有更明显改善,差异有统计学意义(P<0.05)。结论:足部反射区按摩治疗慢性非细菌前列腺炎的机理可能是降低前列腺液中TNF-α、IL-8水平的表达。
Objective: To study the effect of foot reflex zone massage on TNF-α and IL-8 in prostatic fluid in patients with chronic nonbacterial prostatitis. Methods: A total of 96 patients with chronic nonbacterial prostatitis were randomly divided into two groups. The treatment groups were foot reflex zone massage (“kidney”, “ureter”, “bladder” “, ” Prostate “, ” testicle ") plus Qianlie Tongyu capsule, the control group for Qianlie Tongyu capsule, each group of 48 cases. After a course of treatment (4 weeks), the changes of TNF-α and IL-8 levels in the prostatic fluid of the two groups were observed. Results: The mean values of TNF-α in the prostatic fluid before and after treatment were 69.36 ± 12.65 pg / mL and 70.49 ± 7.25 pg / mL in the treatment group and the control group respectively, with no significant difference (P> 0.05) After treatment, they decreased to (54.04 ± 11.08) pg / mL and (59.15 ± 8.38) pg / mL, respectively. There was significant difference between the two groups before and after treatment (P <0.05). The treatment group than the control group had more significant improvement, the difference was statistically significant (P <0.05). The mean pre-IL-8 levels in prostatic fluid of the two groups were (8.03 ± 1.45) ng / mL and (7.94 ± 1.51) ng / mL, respectively, with no significant difference (P> 0.05) (3.76 ± 1.73) ng / mL and (4.42 ± 1.45) ng / mL, respectively. There was significant difference between the two groups before and after treatment (P <0.05). The treatment group than the control group had more significant improvement, the difference was statistically significant (P <0.05). Conclusion: The mechanism of foot reflex zone massage for chronic non-bacterial prostatitis may be to reduce the expression of TNF-α, IL-8 in prostatic fluid.