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目的观察复方二氯醋酸二异丙胺联合还原型谷胱甘肽治疗药物性肝病临床疗效。方法选择61例药物性肝病患者,随机分为两组,对照组30例给予还原型谷胱甘肽1.8g+5%葡萄糖注射液250ml,静脉滴注,1次/d;治疗组31例,在对照组的基础上,给予二氯醋酸二异丙胺40mg+5%葡萄糖注射液250ml,静脉滴注,1次/d。两组均连续治疗4周,于治疗前后观察临床症状及血清总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)变化及不良反应。结果两组治疗4周后,治疗组TBIL、ALT、AST较对照组明显下降(P<0.01)。总有效率治疗组为93.5%,对照组为80%,组间比较差异有统计学意义(P<0.05)。结论复方二氯醋酸二异丙胺联合还原型谷胱甘肽治疗药物性肝病疗效可靠。
Objective To observe the clinical efficacy of compound dichloroacetic acid diisopropylamine combined with reduced glutathione in the treatment of drug-induced liver disease. Methods Sixty-one patients with drug-induced liver disease were randomly divided into two groups. In the control group, 30 cases were given 250ml of reduced glutathione 1.8g + 5% glucose injection, once a day, in the treatment group, On the basis of the control group, given 250ml of diisopropylamine dichloroacetate + 5% glucose injection, intravenous infusion, 1 time / d. The two groups were treated for 4 weeks continuously. The clinical symptoms and the changes of serum total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and adverse reactions were observed before and after treatment. Results After 4 weeks of treatment, TBIL, ALT and AST in the treatment group were significantly lower than those in the control group (P <0.01). The total effective rate was 93.5% in the treatment group and 80% in the control group, with significant difference between the two groups (P <0.05). Conclusion Compound dichloroacetic acid diisopropylamine combined with reduced glutathione for the treatment of drug-induced liver disease is reliable.