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早在19世纪中后叶,人们就发现肌醇是肌肉的组成成分,并确证了其六羟基环己烷的化化学结构。本世纪40年代,Jordi在研究细胞膜时发现肌醇是膜磷脂成分之一,从而开创了肌醇研究的纪元。随着研究的深入,1975年Michell等人首次提出磷酸肌醇作为细胞内第二倍使的概念,近十年来,这方面的工作进展很快,人们逐渐弄清了磷酸肌醇的第二信使作用主要是由其两种代谢产物:肌醇三磷酸(Inositol 1,4,5-phosphate,IP_3)及其二酰基
As early as the mid-19th century, it was found that inositol is a component of muscle and confirms its chemical structure of hexahydroxycyclohexane. In the 1940s, Jordi discovered that inositol is one of the components of membrane phospholipids when it comes to studying cell membranes, creating the era of inositol research. With the deepening of research, in 1975, Michell et al. First proposed phosphoinositide as the second intracellular multiplication concept. In the past ten years, the work in this area has progressed rapidly, and people are gradually clarifying the second messenger of phosphoinositide The main role is its two metabolites: Inositol 1,4,5-phosphate (IP_3) and its diacyl