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目的观察人参皂苷Rg3对非小细胞肺癌术后长期生存的影响及机制。方法采用前瞻性随机对照研究方法,将90例患者随机分为Rg3联合化疗组(46例)和单纯化疗组44例,观察各组1、2、3及5年生存率并进行对比分析;血管内皮生长因子(vascular endothelial growth factor,VEGF)及平均微血管密度(Mean vascular dense,MVD)的表达情况与年生存率的关系。结果⑴两组年生存率比较:Rg3联合化疗组1、2、3及5年生存率均高于单纯化疗组,具有明显的生存优势;但三组比较无统计学差异(P>0.05)。⑵VEGF、MVD与年生存率的关系:在90例患者中,VEGF表达阳性同时MVD高表达者34例(高表达组),VEGF阴性同时MVD低表达组患者25例(低表达组),两组比较1、2、3年生存率无统计学意义(P>0.05),低表达组5年生存率明显高于高表达组,有显著性差异(P<0.05)。结论非小细胞肺癌根治术后人参皂苷Rg3与化疗药物联合应用有提高长期生存期的优势,血管内皮生长因子和平均微血管密度与年生存期有关。
Objective To observe the effect and mechanism of ginsenoside Rg3 on long-term survival of non-small cell lung cancer patients. Methods Ninety patients were randomly divided into Rg3 combined chemotherapy group (n = 46) and chemotherapy alone group (n = 44). The survival rates of 1,2,3 and 5-year groups were observed and compared. Blood vessels Relationship between the expression of vascular endothelial growth factor (VEGF) and mean vascular dense (MVD) and the annual survival rate. Results (1) Comparison of annual survival rate between the two groups: 1, 2, 3 and 5-year survival rates of Rg3 combined chemotherapy group were higher than that of chemotherapy alone group, which had obvious survival advantages. However, there was no significant difference between the three groups (P> 0.05). ⑵VEGF, MVD and the relationship between the annual survival rate: In 90 patients, VEGF expression was positive while MVD high expression in 34 cases (high expression group), VEGF negative MVD low expression group of 25 patients (low expression group), two groups The 1-year, 2-year and 3-year survival rates were not statistically significant (P> 0.05). The 5-year survival rate of low expression group was significantly higher than that of high expression group (P <0.05). Conclusion The combined application of ginsenoside Rg3 and chemotherapeutic drugs has the advantage of improving long-term survival after radical gastrectomy for non-small cell lung cancer. Vascular endothelial growth factor and mean microvessel density are related to annual survival.