甲基杀虫脒盐酸盐作为一种化学诱变物具有一定致突变性。本研究设计中突变的最低剂量组1/50LD50=4.48mg/kg体重,在小鼠骨髓细胞微核出现率中,与对照组比较,呈极显著性差异。因此,无作用剂量组应低于4.5mg/kg体重。染色体畸变的最低剂量在1/5LD50与阴性对照组有极显著性差异,染色体畸变的无作用剂量在8.95～44.76mg/kg范围内。 Methyl chlordimeform hydrochloride has some mutagenicity as a chemical mutagen. In the study design, the lowest dose of mutation group 1 / 50LD50 = 4.48mg / kg body weight, in the incidence of micronuclei in mouse bone marrow cells compared with the control group, showed a very significant difference. Therefore, no effect dose group should be less than 4.5mg / kg body weight. The lowest dose of chromosomal aberration in 1 / 5LD50 and negative control group has a very significant difference in the role of chromosomal aberration dose in the range of 8.95 ~ 44.76mg / kg.