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目的分析轻型再生障碍性贫血(MAA)患儿的转归。方法回顾性分析1996年1月-2009年1月在我院治疗的43例MAA患儿的临床资料。所有患儿诊断后均按照患儿家长意愿选择以下三种治疗方案中的一种:中药组(Ⅰ组,3例):只接受中药治疗;雄激素+中药组(Ⅱ组,10例):接受中药联合康力龙[0.1 mg/(kg.d)]治疗;环孢菌素A+雄激素+中药(Ⅲ组,30例):接受环孢菌素A、康力龙[0.1 mg/(kg.d)]及中药治疗。中位随访时间为42个月(5～116个月)。结果在随访时间内,Ⅰ组3例患儿中仅有1例获得部分缓解,1例在随访73个月时进展为重型再生障碍性贫血(SAA),1例无效;Ⅱ组10例患儿中有3例(30%)获得部分缓解,其余7例(70%)均无效,无一例进展为SAA;Ⅲ组30例患儿中有9例(30%)获得完全缓解,5例(17%)获得部分缓解,1例(3%)在随访至11个月时进展为SAA,其余15例(50%)无效。结论早期给予干预的MAA患儿进展为SAA比率较低。
Objective To analyze the outcome of children with mild aplastic anemia (MAA). Methods The clinical data of 43 MAA children treated in our hospital from January 1996 to January 2009 were retrospectively analyzed. All children were diagnosed according to the wishes of their parents choose one of the following three treatment options: Chinese medicine group (Ⅰ group, 3 cases): only received traditional Chinese medicine treatment; Androgen + Chinese medicine group (Ⅱ group, 10 cases): (0.1 mg / (kg · d)] for treatment of Chinese medicine combined with cyclosporin A + and Chinese herbal medicine (group Ⅲ, 30 cases) ] And Chinese medicine treatment. The median follow-up time was 42 months (range 5 to 116 months). Results At follow-up, only 1 of 3 patients in group Ⅰ was partially relieved, 1 patient developed severe aplastic anemia (SAA) at 73 months of follow-up, 1 patient was ineffective, and 10 patients in group Ⅱ (30%) were partially relieved, while the remaining 7 cases (70%) were ineffective and none of them progressed to SAA. Nine of 30 patients (30%) in group Ⅲ achieved complete remission and 5 (17 %) Achieved partial response, 1 (3%) progressed to SAA at follow-up to 11 months, and the remaining 15 (50%) were ineffective. Conclusions The rate of SAA progression was lower in MAA-treated children who received early intervention.