在75％肝癌患者中可检出丙型肝炎病毒(HCV)抗体,其中40％患者有输血史,所以输血是HCV感染的主要途径。 已基本弄清HCV基因组,HCV属黄病毒属,正链RNA基因。开放阅读框架(ORF)可能产生病毒结构蛋白核心和包膜,在包膜区域(黄病毒E,NS1区域)发现2种糖蛋白(gp35和gp70)。从遗传学上看,HCV可能是一个重组病毒,N＇末端氨基酸源自小核糖核酸病毒科,C＇末端氨基酸来自披盖病毒甲科,基因组5＇端有短非编码区,ORF区较长,负责编码非结构蛋白,糖蛋白和核壳蛋白(N_5区)。 Hepatitis C virus (HCV) antibodies can be detected in 75% of hepatocellular carcinoma patients, of whom 40% have a history of blood transfusions, so blood transfusions are the primary route of HCV infection. The HCV genome has been basically clarified, and the genus of HCV belongs to the genus flavivirus and the positive strand RNA gene. The open reading frame (ORF) may produce viral structural protein core and envelope, two glycoproteins (gp35 and gp70) found in the envelope region (Flavivirus E, NS1 region). From a genetic point of view, HCV may be a recombinant virus, the N terminal amino acids are derived from Picornaviridae, the C terminal amino acids are from the Caenorhabditisae, the genome has a short non-coding region at the 5 ’end and a long ORF region , Responsible for encoding non-structural proteins, glycoproteins and nucleocapsid proteins (N_5 region).