临床治疗学正日趋复杂化。人们已习惯于这样一些相互作用,如地高辛和奎尼丁之间或华法令和阿司匹林之间。作者提醒人们注意,药物如乙胺碘呋酮可引起激素功能的改变(甲状腺机能减退),这一改变又反而提高了同时所用药物(地高辛)的血浆浓度。另外,这两种药物间存在着直接的相互作用,也致使血浆地高辛水平提高。这些相互作用积蓄的效果可致症状的心搏缓慢。心搏缓慢是地高 Clinical therapeutics are increasingly complicated. People have become accustomed to such interactions as digoxin and quinidine or between warfarin and aspirin. The authors caution that drugs such as amiodarone can cause changes in hormonal function (hypothyroidism), which in turn increases the plasma concentrations of concurrent drugs (digoxin). In addition, there is a direct interaction between the two drugs, which also leads to an increase in plasma digoxin levels. The effect of these interactions accumulating may be slow to symptomatic heartbeat. Slow beats are high